In AD, the brain shows hallmark features of amyloid beta (A) plaque accumulation and neurofibrillary tangles formed by hyperphosphorylated tau protein [2], although prior to diagnosis, a series of neuropathological changes and cognitive decline occur [3]
MCGs statewide network now includes four-year campuses in Augusta, Athens and Savannah, and regional clinical campuses in Albany, Brunswick, Dalton, Rome and Savannah, making it one of the largest medical school networks in the country
The slices were stained with 4, 6-diamidino-2-phenylindole and subjected to fluorescence microscopic analysis as previously described 47,48
Following the treatment with GLP-1, the phosphorylation of JNK and its signal transduction through the cyclic adenosine monophosphate/protein kinase A (PKA) signaling pathway was attenuated, while the phosphorylation of STAT3 was increased, which further induce the polarization of macrophage towards M2 (35)