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PUFAs, due to the inherent instability of their bis-allylic hydrogen atoms, are highly vulnerable to oxidative damage and act as the primary substrates for ferroptotic signaling (69)

With provision of exogenous testosterone helping to restore this blunting somewhat (Gharahdaghi et al., 2019), the influence of testosterone on muscle may be small and permissive in the young, but the need for hormonal input for the control of muscle mass may be more important as we age to overcome age-related deficits in the responsiveness of older muscle to exercise training

doi: 10.1024/0300-9831.74.4.269 254