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While many drugs in this class were initially approved to treat type 2 diabetes, they have also been approved for weight loss

Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist

Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks (49, 50)

To investigate the role of GLP-1R in central sensitization, calcitonin gene-related peptide (CGRP) and c-fos were determined using western blotting and immunofluorescence