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Studies tracking generic drug prices since the late 2000s show that many commodity generics are priced at a fraction of their levels a decade ago the result of aggressive purchasing by pharmacy chains, PBMs, and group purchasing organizations (GPOs), combined with increasing consolidation among buyers and global supply chain expansion [31]

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In a diabetes-driven kidney disease model, Glp1r / mice with streptozotocin-induced diabetes exhibited spontaneous kidney dysfunction and accelerated kidney damage as evidenced by their higher albumin-to-creatinine ratios, increased fibronectin levels, and lower cystatin C levels in the urine (70)