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Patients who combine tirzepatide with structured lifestyle interventions consistently achieve superior results compared to medication alone

We outline major translational and biological challenges, identify key gaps for future research and discuss emerging approaches aimed at achieving durable and scalable obesity treatment

Research has shown that patients on newer weight loss medications consume significantly less food overall, which means less dietary vitamin B12 coming in

Therefore, weight regain is common in various weight loss strategies and it is necessary to establish the long-term anti-obesity treatment in clinical practice