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Why It Works: GLP-1 and GIP reduce hunger and improve insulin sensitivity Glucagon receptor activation increases energy expenditure and fat oxidation 2

Nutritional status should be reassessed every 3-6 months, including B12, iron, and calcium levels, as GLP-1 therapy can slightly reduce nutrient absorption when combined with surgery's existing impact

Heres a breakdown of the costs of oral GLP-1s without insurance: *Note: information about orforglipron is based on clinical trials because it has not yet been approved by the FDA

Altogether, the orexigenic and anabolic properties of ghrelin renders the ghrelin-GOAT-GHSR1a axis an attractive anti-obesity target