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To maximize sample sizes whilst aligning with guideline-recommended target populations for these therapies, different whose patient characteristics were independently well-matched: (1) CV outcomes among people with T2D and ASCVD, (2) glucose and weight outcomes among people with T2D, and (3) renal outcomes in people with T2D and CKD [6]

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however, those on high cholesterol diet presented worse glucose lowering responses to exendin-4 versus chow-fed mice (Figure 1A, B), an effect that was maintained when normalised to the corresponding vehicle control (Figure 1C)