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With respect to the wider GLP-1 drug class, the UK SmPCs for semaglutide (available on the electronic Medicines Compendium, emc) and tirzepatide (Mounjaro SmPC, emc) document GI adverse effects including nausea, vomiting, diarrhoea, constipation, and dyspepsia as well-characterised class effects
Prasad-Reddy L, Isaacs D
Fiber) study recently highlighted, your gut needs to be primed. If your microbiome isnt diverse, all that fiber might just cause bloating
Divergence across payer type matters: Commercial patients adopt GLP1s earlier and often remain on monotherapy, while Medicare patients face stricter controls and higher comorbidity burdens
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