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Nutrition refinement: Increase protein to 0.7-1.0g per pound of goal body weight Reduce meal frequency if naturally eating less (three meals, no snacking is common) Prioritize nutrient density, each calorie you eat should deliver maximum nutrition Consider meal timing, many tirzepatide users find that eating earlier in the day aligns better with the medication appetite-suppressing peak Behavioral additions: Practice mindful eating (eat slowly, without screens, paying attention to fullness) Identify and address emotional eating triggers Begin to distinguish between physical hunger and habitual eating Protocol 3: weeks 13+ (sustained optimization) Goal: Maintain appetite control while maximizing lean mass preservation

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J Clin Oncol (2020) 38(23):26207