Classical symptoms include: Weight loss Palpitations Anxiety Eye bulging Tremors Irritability Infrequent menstrual periods Fatigue Heat intolerance Increased appetite Hair loss Enlarged thyroid gland Sweating Frequent bowel movements Infertility Soft nails Warm, moist palms Finger tremors Insomnia Muscle weakness Nervousness Symptoms of Hypothyroidism Some of the more common symptoms of hypothyroidism, or deficiency of thyroid hormone, include: Slower metabolism leading to weight gain Forgetfulness Feeling cold or cold intolerance Depression Fatigue Dry skin Constipation Loss of ambition Dry, coarse hair Muscle cramps Stiffness Joint pain A loss of the outer third eyebrow Heavy menstrual periods Infertility Muscle aches Puffy face Slow heartbeat Brittle nails Arthritis These symptoms may be present in any combination in people with thyroid disorders, but the degree to which they impact an individual can vary greatly as well

After single IM administration at doses of 6, 30, or 150 g/kg, the T max values of each dose were 6.33, 8.67, and 8.17 min, respectively
Lactated Ringers injection and 5% Dextrose injection (D5W) have also been found to be compatible with hydroxocobalamin and may be used if 0.9% NaCl is not readily available
Before initiating the determination of MIC B12 injection dosage, a healthcare provider will conduct a comprehensive assessment of the individual's health