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Additional benefits of site rotation include: Reduced risk of injection site reactions such as erythema, bruising, or tenderness Decreased likelihood of developing scar tissue that may impede absorption Improved patient comfort and treatment adherence More consistent drug delivery According to Forum for Injection Technique (FIT UK) recommendations, patients should maintain a systematic rotation pattern, rotating both within and between injection regions

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As a result, the daily food intake and cumulative food intake for 10 days in DIO mice administered ISF were reduced to the levels close to those of lean mice ( Figures 6C, F ) , and the body weight gain was inhibited by subchronic ISF administration ( Figures 6G, H )