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This protection is likely due to increased growth of new neurons in the hippocampus, improved signaling of brain-derived neurotrophic factor (BDNF), better synaptic function, and reduced brain inflammation (Nichol et al., 2008)

Electron paramagnetic resonance (EPR) and spin trapping EPR with spin traps (e.g., DMPO/DEPMPO families) provides direct radical evidence and kinetics but typically requires higher concentrations and controlled matrices