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The 2010 RCT of 42 hirsute PCOS women showed measurable testosterone reduction and subjective hirsutism improvement on twice-daily spearmint tea (Grant 2010), and the earlier clinical trial established the anti-androgenic mechanism (Akdoan et al

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2 and Supplementary Table 3) fulfilled all these criteria and included 1) HIF1A transcription factor network (pink), 2) hypoxic and oxygen hemostasis regulation of HIF1A (black), 3) Vascular Endothelial Growth Factor (VEGF) hypoxia and angiogenesis (blue), 4) HIF2A transcription factor network (green), 5) signaling by Transforming Growth Factor- (TGFB) receptor complex (brown), 6) signaling by Platelet Derived Growth Factor (PDGF, yellow), and 7) hypoxia response by HIF activation pathways (orange)