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These factors collectively contribute to myocardial cell injury and death, affecting both systolic and diastolic cardiac function while promoting adverse myocardial remodeling and eventual heart failure progression ( 2.2 Definition and characterization of ferroptosis The mechanisms of ferroptosis are illustrated in Figure 1

Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity

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400 The MonarcHER study similarly indicates the potential for combining CDK4/6 inhibitors with fulvestrant as a companion to trastuzumab