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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway

Its important to note that weight loss outcomes also depend on concurrent lifestyle interventions, such as diet and exercise, and the optimization of thyroid hormone replacement therapy

Concerns about ozempic and thyroid disorders stem from the interplay between metabolism, weight, and endocrine balance

10.1016/j.bbrc.2018.12.039 Biochem