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The standard escalation protocol is: Weeks 14 : 0.25 mg once weekly Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) Patients who experience persistent hunger during the early titration phases should understand that appetite suppression typically increases with higher doses

Similarly, a population-based cohort study using Taiwanese claims data did not demonstrate a significant increase in depression risk among GLP-1RAs users compared with non-users.177 Research on mental health outcomes beyond depression, including health-related quality of life and anxiety, suggests potential improvements associated with GLP-1RAs treatment.175177 Some clinical and preclinical studies have indicated the anxiolytic effects of GLP-1RAs

Roughly the same proportion of patients received iron during the course of the study, although the ferritin concentration (a marker of iron stores and of inflammation) was higher on average in the placebo group

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