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[1] [8] They also act on receptors in the central nervous system, particularly in hypothalamic regions that regulate appetite and satiety

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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

The medications pharmacokinetics allow for once-weekly dosing, and research continues to evaluate long-term cardiovascular outcomes