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In a 2003 study using a largescale screening experiment to explore the killing effect of various chemical compounds on tumour cells, Stockwell et al

But if study endpoints measure lasting structural brain changes, synaptic density, neuroprotection, or recovery from injury, the biological evidence supports intermittent administration

10.7326/M24-0859 Ann

Crucially, most neurodegenerative phenotypesparticularly late-onset formsare polygenic and multifactorial, frequently arising from variants of incomplete penetrance and variable expressivity