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4 Discussion The results of these two studies found no clinically relevant differences in cagrilintide pharmacokinetics in people with renal or hepatic impairment, regardless of severity

Conclusions Amylin, a neuroendocrine hormone co-secreted with insulin, is deficient in individuals with diabetes and plays an important role in postprandial glucose homeostasis by suppressing glucagon secretion and delaying gastric emptying

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As for clinical correlates, Vit B12 deficiency and HHcy do predict more rapid motor progression and cognitive dysfunction among PwPD and thus modulate PD clinical phenotypic variability