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oversupplementation in general is more clearly linked to problems with vitamin A or selenium than B12

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Science 371 , 265270 (2021)

Despite normalization of plasma homocysteine concentration, administration of folic acid, vitamin B 6 , and vitamin B 12 for 6 months was insufficient to restore normal vascular function in monkeys maintained for 17 months on an atherosclerotic diet that produced both hypercholesterolemia and hyperhomocysteinemia (Lentz et al, 1997)