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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)

Kong L, Zhao Q, Jiang X, Hu J, Jiang Q, Sheng L, et al

Friedreichs ataxia: clinical features, pathogenesis and management

Patel currently serves as CEO of Virginia Mason Franciscan Health and president of the Pacific Northwest Region of CommonSpirit Health