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In the M-ARCOL model (Mucosal Artificial Colon, an advanced in vitro system using microbiota from healthy donors), daily exposure to PEMPs for 14 days increased pathobiont Desulfovibrionaceae (Fournier et al., 2023)

Future investigations should focus on understanding the role of NLRP3 at different phases of APAP-induced liver injury, its activation in various cell types, including hepatocytes and Kupffer cells, and validating its involvement in liver damage in multiple animal models through comparative analyses

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide structurally related to a protein naturally found in human gastric secretions

The complex interplay between the gut microbiome, the enteric nervous system, and the brain is facilitated by direct neural connections and indirect endocrine and immunological pathways (449)