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The concentration of unphosphorylated receptor at steady state, z * = [ Z ] ss /Z tot , is decided from r 1 ( z * ) = r 2 ( z * ), The state of the receptor changes in the range of 0 z * 1 in response to the relative rate of de-phosphorylation and phosphorylation (or the relative amount of kinase and phosphatase) in the cell ( v 1 /v 2 = k 1 P o /k 2 K o )

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[363] The numerator thresholds were developed according to evidence and consensus-based clinical guidelines for ED time thresholds from a TEP and environmental scans