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No, L Carnitine dosage does not need cycling

The mechanistic case is strong

Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells

Concerning the species used in Pendulums products, most of them have been found to impart health benefits at much lower quantities: 1 million CFU8 Clostridium butyricum: 10 million CFU in animal models9 Clostridium beijerinckii: 100 million CFU in animal models10 Anaerobutyricum hallii (formerly Eubacterium hallii ): 100 million CFU11 Bifidobacterium infantis: 100 million CFU12 Akkermansia muciniphila: Theres no direct translation between CFU and AFU, but these numbers should give you a sense of Pendulums efficacy with respect to viable bacterial quantity