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Description

Seino, Y

As with other incretin-based therapies, the most commonly reported side effects include nausea, vomiting, diarrhea and constipation, particularly during dose escalation

2019;7:8990 [PubMed]

Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)