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The reader is referred to recent reviews addressing the pathophysiology of focal and diffuse TBI including diffuse axonal injury, a common consequence of TBI (Andriessen et al., 2010

Based on visual inspection during the experimental period (3538 weeks old), MC4R KO mice appeared to have a longer body length compared to wild-type controls, which is consistent with the findings reported by Braun et al

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Local injection may enhance effects at the injury site