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We found that prolonged exendin-4-induced insulin secretion was increased in INS-1 832/3 and MIN6B1 cells after treatment with small interfering RNA (siRNA) to silence both -arrestins, and also in human EndoC-H1 40 beta cells lentivirally transduced with -arrestin-1 and -arrestin-2 small hairpin RNA (shRNA) (Fig
Growth hormone and nonalcoholic fatty liver disease
PMID 9684736
In Phase 2, participants were randomized to multiple doses, such as: 1 mg fixed dose 4 mg, starting at 2 mg or 4 mg 8 mg, starting at 2 mg or 4 mg 12 mg, starting at 2 mg All doses were administered subcutaneously once weekly, and dose escalation was intended to improve tolerability
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