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Routine measurement of serum calcitonin (a marker for C-cell pathology) is not recommended by most guidelines, as its value for screening in the general population is limited by poor specificity and the rarity of medullary thyroid carcinoma

Pharmaceutical manufacturers are reporting widespread instances of patients quitting their clinical trials prematurely once they realize theyve been assigned a placebo instead of the real thing, raising questions about how trials for obesity drugs should be run moving forward

Second, the interval between vitamin D measurement and semaglutide initiation was not included in the analysis, which may introduce exposure misclassification

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