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Although technically challenging, this should be further investigated, especially in light of the neuroimaging findings in ME/CFS, described in the following paragraphs
Our recent SNO-proteome analysis of the cortices of Shank3 InsG3680 (+/+) mutant mice showed that several mitochondrial processes, including the ATP metabolic process, transmembrane electron transport, and the cellular response to oxidative stress, were SNO-enriched [64]
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Assessment of these studies is complicated by the use of membranes of different composition, attainment of different Kt/V levels, short study duration, and inclusion of patients not on ESA therapy
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