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Plasma exposure of PF-06882961, as measured by AUC inf and C max , appeared to increase in an approximately dose-proportional manner, with mean t 1/2 ranging from 4.3 to 6.1 hours (Fig

Should be preferred: Applied when at least one Phase III randomized controlled trial with prespecified, phenotype-specific primary endpoints demonstrated clinically meaningful benefit, with regulatory approval and no major safety concerns