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The NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, though there is generally no benefit to such excessive amounts without confirmed deficiency
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B12 has been proven to increase the cognitive function of older people and has even been used to prevent or slow the progression of dementia
(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)
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