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Long acting agonists appear to penetrate permeable areas of the blood-brain barrier and act directly on neurons with GLP-1R in the paraventricular nucleus (PVN) and Area Postrema (56, 102, 105)

Some patients on semaglutide report less frequent meals due to reduced appetite, which can actually make medication timing easier

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This includes: Your Ozempic or Wegovy pen or your vial of compounded semaglutide Gauze pad, cotton ball, or alcohol swabs to clean the injection site A new sterile needle (Ozempic only) A sterile syringe (compounded semaglutide only) Your sharps disposal container Ensure the medication looks safe to use