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Post hoc analysis of LEADER data revealed a persistent increase in the overall risk of biliary tract-related events and gallbladder diseases, consistently observed across four categories: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction [34]
Studies in elderly populations, who share some constipation mechanisms with GLP-1 users (slower transit, reduced food intake), showed significant improvements in bowel movement frequency
5 A number of reasons have been suggested for this lack of efficacy in certain individuals, ranging from genetic mutations causing poor responses to pharmacokinetic differences and concomitant medical conditions
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