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This survey revealed that participants mainly described benefits and positive outcomes from the diet

GLP-1 Receptor Activation Metabolic Regulation GLP2 activates GLP-1 receptors with lower potency than endogenous GLP-1 but demonstrates biased signaling properties: Preferential cAMP pathway activation over beta-arrestin recruitment, which may enhance insulin secretory responses Suppression of inappropriately elevated glucagon secretion during hyperglycemia Reduced GLP-1 receptor internalization compared to native GLP-1, potentially extending signaling duration Contribution to glucose-dependent insulin secretion complementary to GIP receptor effects Research in isolated pancreatic islets demonstrated that GLP2s insulinotropic actions depend on GIP receptor presence, with the biased GLP-1 receptor signaling providing synergistic enhancement

[18] [19] Lifestyle modification including dietary change and increased physical activity remains the cornerstone of MASLD/NAFLD management per NICE guideline NG49, but many patients struggle to achieve or sustain sufficient weight loss through lifestyle measures alone

However, retatrutide is still in Phase 3 trials and does not yet have FDA approval