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The concern is that improved ovulation in previously anovulatory women increases fertility, and rapid weight loss may affect oral contraceptive absorption if you're having GI side effects

Before starting treatment, it is imperative to exclude that the edema is of systemic origin, such as in cases of heart, kidney, or liver failure, where the efficacy of vasoprotectants is not documented [EMA]

At one year, if the patient is clinically and biochemically euthyroid and a thyroid-stimulating antibody level is not detectable, therapy can be discontinued

Redox-associated metabolic responses By the age of 12-mo, commensals anaerobes (e.g., Bifidobacterium, Bacteroides , Clostridium ) are colonized 1001000 times more frequently than aerobic bacteria due to a substantial increase in the populations of facultative bacteria throughout infancy (e.g., Enterobacteriacea e, Enteroccocus , Streptococcus ) 87