NAD, a prolongevity molecule, has been a topic of interest for its potential to increase lifespan, but it has been clarified that it does not increase lifespan, and its effects on humans are still being studied, with some people using NMN to upregulate NAD for its energy-boosting effects 2m6s
Their structure comprises a conjugated sp 2 carbon core and an sp 3 -hybridized surface enriched with oxygen-containing groups such as hydroxyl, carbonyl, and carboxyl moieties [Figure 1A)
The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)
While hEDS does not have a confirmed affected gene, it is believed to follow an autosomal dominant pattern of inheritance, like vEDS