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The decision affects a class of drugs known as GLP-1s, which are used to treat diabetes along with helping with weight loss

The phosphorylation status of mTORC1 substrates including S6 S240/S244 and 4E-BP1 T37/S46 were assessed in the brain along with autophagy receptor p62 (sequestosome 1, SQSTM1) and the autophagosome marker LC3A/B

Another CUR derivative, MitoCur-1 has been shown to significantly inhibit tumor growth by triggering ferroptosis in melanoma and enhancing sensitivity to vemurafenib-resistant cells

The mean age ranged from 18101 years and baseline BMI of included studies ranged from 22.19 to 36 kg/m 2 in the intervention group, respectively