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Lipotropic compounds support ongoing hepatic lipid metabolism rather than providing acute metabolic effects, so one missed dose wont cause rebound fat gain or metabolic slowdown

For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135

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