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Melanotan I (also known as afamelanotide) acts on MC1R and has increased resistance to enzymatic breakdown, whereas melanotan II is a shorter cyclic variant that increases pigmentation at a lower cumulative dose and is less specific and more lipophilic, thereby crossing the blood-brain barrier more easily, leading to more widespread adverse effects

All MD simulations were performed with the program package GROMACS (version 2020.4) 32 using the GROMOS 54a7 force field 33

Two new biosimilars of denosumab have been approved by the FDA, which are generics of Prolia/ Xgeva

When bone mineralization is compromised, osteoblasts produce an excessive quantity of alkaline phosphatase, resulting in elevated levels of ALP