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Abbreviations ACN: Acetonitrile DMEM: Dulbeccos Modified Eagle Medium E/e: Ratio of early diastolic maximum transmitral inflow velocity (E) to early diastolic tissue velocity at the mitral valve annulus (e) ESI-MS/MS: Electrospray ionization tandem mass spectrometry FCS: Fetal calf serum FIA-MS/MS: Flow-injection MS/MS system FMO3: Flavin-containing mono-oxygenase 3 HBSS: Hanks balanced salt solution HF: Heart failure HFpEF: Heart failure with preserved ejection fraction LVEF: Left ventricular ejection fraction L-ZSF1: Lean ZSF1 rats MGV: Mean gray value MRM: Multiple reaction monitoring MS: Mass spectrometry NO: Nitric oxide NT-proBNP: N-terminal pro-brain natriuretic peptide OTU: Operational taxonomic unit O-ZSF1: Obese ZSF1 rats PAS: Periodic acid shift PBS: Phosphate-based saline ROI: Region of interest SDMA: Symmetric dimethylarginine TMA: Trimethylamine TMAO: Trimethylamine-N-oxide ZO1: Zona occludens protein 1 ZSF1: F1 hybrids crossed from Zucker diabetes fatty (ZDF)-rats with male spontaneously hypertensive heart failure (SHHF)-rats References McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bhm M, et al

The study found that all efpeglenatide dosages notably decreased body weight, showing reductions between 6.3 and 7.2 kg compared to the placebo

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Some providers recommend additional contraceptive precautions during the initial months of Retatrutide treatment