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These local effects are generally mild and transient, resolving within minutes to hours after administration

In two studies of 12- and 24-week duration, SGLT2 inhibitors alone (canagliflozin and dapagliflozin, respectively) did not affect HbA1c levels compared to placebo in overweight and obese subjects [29, 30]

Research applications include NNMT pharmacology, methyltransferase signaling studies, enzymatic regulation investigations, and mechanistic evaluation of nicotinamide methylation pathways

The following features would enhance the value of an obesity therapeutic, but would likely be assessed in follow-up trials or even post-approval: Additional efficacy in obesity-related co-morbidities