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Patients with undiagnosed OSA often report worsening insomnia or daytime fatigue when starting GLP-1 therapy because rapid weight loss in the first 12 months can shift upper airway tissue distribution

As a result, individuals may experience steady weight loss over time when combined with a healthy diet and regular exercise

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In a more recent randomized, open-label study in 45 RA patients, supplementation with a mixture of all three major curcuminoids (0.5 g/day for eight weeks) was found to be as effective as diclofenac (NSAID