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Among the tested interventions, Bifidobacterium infantis produced the most pronounced effects, showing the greatest reduction in gut-leakiness markers and the strongest upregulation of GABA-receptor expression (Zarezadeh et al., 2023)

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Subsequent work by Sun and colleagues in the APP/PS1 mouse model identified downstream PI3K/AKT pathway activation as a major component of the mechanism, with the PI3K inhibitor wortmannin reversing Dihexas anti-inflammatory and anti-apoptotic effects [5]