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310 Similar effects are observed after transgenic deletion of Ccl2 specifically from astrocytes, which showed little effects early in EAE but demonstrated that astrocyte Ccl2 sustains disease symptoms and inflammation during chronic EAE, making it a therapeutic target

Itching: Severe and often worse at night Rash: Small red bumps, blisters, or pimple-like irritations Burrows: Thin, irregular tracks made by mites under the skin, often found between fingers, wrists, waistline, and genital area Spread: Rash often appears in multiple areas due to mite migration Scabies can sometimes cause crusted or Norwegian scabies, a severe form with thick crusts and widespread skin involvement, especially in people with weakened immune systems