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This metabolic regulatory function may synergize with caloric restriction, which is a strategy proven to impede the development of lupus-like disease in New Zealand Black (NZB) and NZBNew Zealand White (NZW) F1 mice (161, 162)

Although NADPH has multifunctional roles in regulating inflammation, particularly in myeloid cells that have been clearly defined in the past, it remains unclear how NADPH-dependent inflammatory and anti-inflammatory pathways are co-regulated in order to fine-tune the magnitude of an inflammatory response

For musculoskeletal repair or gut health, compounds like BPC-157 or TB-500 may be more targeted

KO, n = 3