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More serious adverse effects that require monitoring include: Pancreatitis (treatment should be discontinued immediately if suspected) Gallbladder disease (cholelithiasis and cholecystitis) Diabetic retinopathy complications (particularly with rapid HbA1c reduction in patients with pre-existing retinopathy) Acute kidney injury (secondary to dehydration from gastrointestinal side effects) Increased heart rate Hypoglycaemia (particularly when used with insulin or sulphonylureas) Understanding the expected side effect profile helps patients distinguish between typical medication responses and symptoms that may warrant further medical evaluation

Global sensitivity analysis is then applied to examine the model behavior and identify the pathways with the greatest impact in control compared to RP conditions

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To date, no formal guidelines exist for treating older, obese adults with the new AOMs, leaving HCPs to carefully consider, on a case by case basis, the benefits of AOM therapy vs