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The "hit-and-clear" model requires rest periods for immune processing Guarantee human results No compound that has only been tested in mice should be assumed to work identically in humans

Methods The open-label, controlled study protocol adhered to the EU Directive (2010/63/EU) for animal experiments and was approved by the local animal ethics committee, Comit Ethique du Bien-tre Animal (protocol number 723N), at the Universit Libre de Bruxelles (ULB) in Brussels, Belgium