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Perhaps most convincingly, rat studies in which plasma glucose and lactate levels were measured in the inferior vena cava, hepatic vein, hepatic portal vein and the aorta demonstrated that the plasma lactate concentration peaks in the hepatic portal vein, with a corresponding drop in the plasma glucose concentration

Data ( b, c, d, e, g, h ) are shown as box-and-whisker plots: boxes indicate the 25th75th percentiles, central lines indicate medians, and whiskers indicate minimum to maximum values

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