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Patent 343 and SNAC U.S

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For example, the enzymatic activity of poly (ADP-ribose) polymerase (PARP)1, a representative NAD + degrading enzyme, increases in various organs such as the liver, kidney, skeletal muscle, lung, and heart owing to the accumulation of DNA damage associated with aging and HFD-induced obesity and correlates with age- and obesity-related changes in NAD + levels [46,56,57,58]

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11,12 Notably, the potential neuroprotective properties of GLP-1 RAs extend to conditions like Alzheimer disease (AD) and Parkinson disease by ameliorating motor impairment and curtailing oxidative stress, inflammation, and apoptosis

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