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Clinical trials have shown the drug helps with weight loss in people with type 2 diabetes
Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue
And the introduction of oral GLP-1 formulations, including the FDA approval of oral semaglutide for chronic weight management, expanded options beyond injectable formats.
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